Doxycycline iv

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  1. Samarik Well-Known Member

    Doxycycline iv


    Doxycycline injection is used to treat or prevent bacterial infections, including pneumonia and other respiratory tract infections. It is also used to treat certain skin, genital, intestine, and urinary system infections. Doxycycline injection may be used to treat or prevent anthrax (a serious infection that may be spread on purpose as part of a bioterror attack) in people who may have been exposed to anthrax in the air. Doxycycline injection is in a class of medications called tetracycline antibiotics. It works by killing bacteria that cause infections. Antibiotics such as doxycycline injection will not work for colds, flu, or other viral infections. Taking or using antibiotics when they are not needed increases your risk of getting an infection later that resists antibiotic treatment. In addition to the general indications for all members of the tetracycline antibiotics group, doxycycline is frequently used to treat Lyme disease, chronic prostatitis, sinusitis, pelvic inflammatory disease, Moraxella catarrhalis, Brucella melitensis, Chlamydia pneumoniae, and Mycoplasma pneumoniae are generally susceptible to doxycycline, while some Haemophilus spp., Mycoplasma hominis, and Pseudomonas aeruginosa have developed resistance to varying degrees. Some Gram-positive bacteria have developed resistance to doxycycline. Up to 44% of Streptococcus pyogenes and up to 74% of S. faecalis specimens have developed resistance to the tetracycline group of antibiotics. When bacteriologic testing indicates appropriate susceptibility to the drug, doxycycline may be used to treat these infections caused by Gram-positive bacteria: The World Health Organization Guidelines states that the combination of doxycycline with either artesunate or quinine may be used for the treatment of uncomplicated malaria due to Plasmodium falciparum or following intravenous treatment of severe malaria. Doxycycline kills the symbiotic Wolbachia bacteria in the reproductive tracts of parasitic filarial nematodes, making the nematodes sterile, and thus reducing transmission of diseases such as onchocerciasis and elephantiasis. Doxycycline has been used successfully to treat sexually transmitted, respiratory, and ophthalmic infections.

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    Doxycycline Injection official prescribing information for healthcare professionals. Includes indications, dosage, adverse reactions, pharmacology and more. Doxycycline Vibramycin, Oracea, Adoxa, Atridox and Others is a prescription drug used to treat a variety of infections. Common side effects of doxycycline may include nausea, diarrhea, abdominal pain, and more. Drug interactions, uses, dosage, and the effects on pregnancy and breastfeeding are provided. DOXYCYCLINE VIBRAMYCIN ® - Intravenous IV Dilution. CLINICAL PHARMACOLOGY Doxycycline is primarily bacteriostatic and thought to exert its antimicrobial.

    When penicillin is contraindicated, doxycycline is an alternative drug in the treatment of the following infections: -Syphilis caused by Treponema pallidum -Yaws caused by Treponema pallidum subspecies pertenue -Listeriosis due to Listeria monocytogenes -Vincent’s infection caused by Fusobacterium fusiforme -Actinomycosis caused by Actinomyces israelii -Infections caused by Clostridium species CDC STD guidelines: MMWR Recomm Rep. June 5, 20(RR3);1-137 Uncomplicated gonococcal infection of the cervix, urethra, and rectum: Ceftriaxone 250 mg IM once plus azithromycin 1 g PO once (preferred) or alternatively doxycycline 100 mg PO q12hr for 7 days Uncomplicated urethral, endocervical, or rectal infection caused by Chlamydia trachomatis: 100 mg PO BID x 7 days Nongonococcal urethritis caused by C. urealyticum: 100 mg PO BID x 7 days Syphilis (early): Patients who are allergic to penicillin should be treated with doxycycline 100 mg PO BID x 2 weeks Syphilis 1 year duration: Patients who are allergic to penicillin should be treated with doxycycline 100 mg PO BID x 4 weeks Acute epididymo-orchitis caused by N. gonorrhoeae or C trachomatis: 100 mg PO BID x least 10 days Equivalent dose of Doryx MPC is 120 mg PO BID Trachoma caused by Chlamydia trachomatis, although the infectious agent is not always eliminated as judged by immunofluorescence; also approved for inclusion conjunctivitis caused by chlamydia trachomatis 100 PO q12hr on day 1, then 100 mg PO q Day Equivalent dose of Doryx MPC is 120 mg PO q12h on day 1, then 120 mg PO q Day Indicated for Rocky Mountain spotted fever, typhus fever and the typhus group, Q fever, rickettsial pox, and tick fevers caused by Rickettsiae 100 PO q12hr on day 1, then 100 mg PO q Day Equivalent dose of Doryx MPC is 120 mg PO q12h on day 1, then 120 mg PO q Day Suspected Bartonella infection with a negative culture: 100 mg PO BID x 6 weeks in combination with gentamicin and ceftriaxone Positive culture Bartonella infection: 100 mg PO BID x 6 weeks in combination with gentamicin or rifampin Equivalent dose of Doryx MPC is 120 mg PO BID Single dose: 7 mg/kg PO/IV; not to exceed 300 mg/dose; adjunct to fluid and electrolyte replacement Multiple dose: 2 mg/kg PO/IV twice daily on day 1; THEN, 2 mg/kg q Day on days 2 and 3; not to exceed 100 mg/dose; adjunct to fluid and electrolyte replacement Anorexia Dental discoloration Diarrhea Dysphagia Enterocolitis Erythema multiform Esophageal ulcer Esophagitis Exacerbation of systemic lupus erythematosus Exfoliative dermatitis Glossitis Headache Hemolytic anemia Hepatotoxicity Hypoglycemia Inflammatory anogenital lesion Intracranial hypertension Nausea Neutropenia Pericarditis Serum sickness Skin hyperpigmentation Toxic epidermal necrolysis Thrombocytopenia Upper abdominal pain Urticaria Vomiting Drug rash with eosinophilia and systemic symptoms Not drug of choice for any staphylococcal infection Risk of thrombophlebitis when given IV History of candidiasis overgrowth Hepatotoxicity may occur; if symptoms occur, measure LFTs and discontinue drug Photosensitivity may occur with prolonged exposure to sunlight or tanning equipment; reduce dose in renal impairment May increase BUN due to its anti-anabolic effects; use caution in patients with renal impairment Consider drug serum level determinations in prolonged therapy Tetracycline use during tooth development (last half of pregnancy through age 8 years) can cause permanent discoloration of teeth; use doxycycline in pediatric patients 8 years of age or less only when potential benefits expected to outweigh risks in severe or life-threatening conditions (e.g., anthrax, Rocky Mountain spotted fever); particularly when there are no alternative therapies Superficial discoloration of adult permanent dentition, reversible upon drug discontinuation and professional dental cleaning has reported; permanent tooth discoloration and enamel hypoplasia may occur with drugs of tetracycline class when used during tooth development Fanconi-like syndrome may occur with outdated tetracyclines Intracranial hypertension (pseudotumor cerebri) reported (rare) may occur; symptoms include headache, blurred vision, diplopia, and vision loss; papilledema can be found on funduscopy; women of childbearing age who are overweight or have a history of IH are at greater risk; possibility for permanent visual loss exists; if visual disturbance occurs during treatment, prompt ophthalmologic evaluation is warranted; intracranial pressure can remain elevated for weeks after drug cessation; monitor patients until they stabilize Doxycycline offers substantial but not complete suppression of asexual blood stages of Plasmodium strains; doxycycline does not suppress P. falciparum’s sexual blood stage gametocytes; subjects completing prophylactic regimen may still transmit infection to mosquitoes outside endemic areas Prolonged use may result in superinfection Overgrowth of non-susceptible organisms, including fungi, may occur; if such infections occur, discontinue use and institute appropriate therapy May induce hyperpigmentation in many organs including skin, eyes, nails, thyroid and bone If Clostridium difficile associated diarrhea suspected or confirmed, may need to discontinue ongoing antibacterial use not directed against C. difficile; may also need to institute appropriate fluid and electrolyte management, protein supplementation, antibacterial treatment of C. difficile, and surgical evaluation as clinically indicated Use in pediatric patients 8 years of age or less only when potential benefits are expected to outweigh risks in severe or life-threatening conditions (e.g., anthrax, Rocky Mountain spotted fever), particularly when there are no alternative therapies Severe skin reactions, such as exfoliative dermatitis, erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis, and drug reaction with eosinophilia and systemic symptoms (DRESS) reported; if severe skin reactions occur, discontinue therapy immediately and institute appropriate therapy Not studied in pregnant patients; the vast majority of reported experience with doxycycline during human pregnancy is short-term, first trimester exposure; there are no human data available to assess effects of long-term therapy of doxycycline in pregnant women, such as that proposed for treatment of anthrax exposure; it should not be used in pregnant women unless, in judgment of physician, it is essential for welfare of patient; evidence of embryotoxicity has been noted in animals treated early in pregnancy Tetracyclines are excreted in human milk; however, extent of absorption of tetracyclines, including doxycycline, by breastfed infant is not known; short-term use by lactating women is not necessarily contraindicated; however, effects of prolonged exposure to doxycycline in breast milk are unknown;11 because of potential for serious adverse reactions in nursing infants from doxycycline, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account importance of drug to mother Inhibits protein synthesis and, thus, bacterial growth by binding to 30S and possibly 50S ribosomal subunits of susceptible bacteria; may block dissociation of peptidyl t-RNA from ribosomes, causing RNA-dependent protein synthesis to arrest. Solution: D5W, NS Additive: Ranitidine Syringe: Doxapram Y-site (partial list): Acyclovir, amiodarone, aztreonam, hydromorphone, linezolid, Mg SO4, meperidine, meropenem (comp at 1 mg/m L mero and 1 mg/m L doxy; incomp at 50 mg/m L mero and 1 mg/m L doxy), morphine SO4, propofol, remifentanil The above information is provided for general informational and educational purposes only. The authors make no claims of the accuracy of the information contained herein; and these suggested doses and/or guidelines are not a substitute for clinical judgment. nor any other party involved in the preparation of this document shall be liable for any special, consequential, or exemplary damages resulting in whole or part from any user's use of or reliance upon this material. Doxycycline in these solutions is stable under fluorescent light for 48 hours, but must be protected from direct sunlight during storage and infusion. Susceptibility Plate Testing: If the Kirby-Bauer method of disc susceptibility is used, a 30 mcg doxycycline disc should give a zone of at least 16 mm when tested against a doxycycline-susceptible strain. PLEASE READ THE Reconstituted solutions (1 to 0.1 mg/m L) may be stored up to 72 hours prior to start of infusion if refrigerated and protected from sunlight and artificial light. Solutions must be used within these time periods or discarded. Doxycycline is primarily bacteriostatic and thought to exert its antimicrobial effect by the inhibition of protein synthesis. A tetracycline disc may be used to determine microbial susceptibility. Doxycycline is stable for 48 hours in solution when diluted with Sodium Chloride Injection, USP, or 5% Dextrose Injection, USP, to concentrations between 1 mg/m L and 0.1 mg/m L and stored at 25°C. Doxycycline is active against a wide range of gram-positive and gram-negative organisms. is 4 to 12.5 mcg/m L and resistant (not likely to respond to therapy) if the M. If the Kirby-Bauer method of disc susceptibility is used, a 30 mcg tetracycline disc should give a zone of at least 19 mm when tested against a tetracycline-susceptible bacterial strain. The drugs in the tetracycline class have closely similar antimicrobial spectra, and cross resistance among them is common. Microorganisms may be considered intermediate (harboring partial resistance) if the M. Tetracyclines are readily absorbed and are bound to plasma proteins in varying degree. Microorganisms may be considered susceptible to doxycycline (likely to respond to doxycycline therapy) if the minimum inhibitory concentration (M. They are concentrated by the liver in the bile, and excreted in the urine and feces at high concentrations and in a biologically active form. Following a 100 mg single dose administered in a concentration of 0.4 mg/m L in a one-hour infusion, normal adult volunteers average a peak of 2.5 mcg/m L, while 200 mg of a concentration of 0.4 mg/m L administered over two hours average a peak of 3.6 mcg/m L.

    Doxycycline iv

    INTRAVENOUS - Food and Drug Administration, Doxycycline Vibramycin, Oracea Side Effects, Dosage & Uses

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  7. Doxycycline is available in multiple generic forms in capsules and tablets ranging from 20 to 100 mg, and as oral suspensions for pediatric use. Typical adult doses are 100 to 200 mg twice daily for 7 to 30 days. Parenteral forms for intravenous or intramuscular administration are also available.

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    Minimum Inhibitory Concentrations mcg/mL Disk Diffusion zone diameter in mm Pathogen. S. I. R. S. I. R. Enterobacteriaceae. M100 standard is recognized. Acinetobacter spp. M100 standard is. Doxycycline, like other tetracycline antibiotics, is bacteriostatic. It works by preventing bacteria from reproducing through the inhibition of protein synthesis. Detailed Doxycycline dosage information for adults and children. Includes dosages for Bacterial Infection, Urinary Tract Infection, Acne and more; plus.

     
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