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    Privacy Statement At Wilson-Hite Insurance, Inc., we are committed to protecting your privacy as a visitor to this Web site and as our customer. To our visitors and to our customers, we offer this pledge: Wilson-Hite Insurance is the owner of the information, which is collected on this Web site. PACKAGE LEAFLET: INFORMATION FOR THE USER What Phenergan Tablets are used for Phenergan Tablets are used to treat the following conditions: • For short term use: to treat adults with difficulty sleeping (insomnia) • To treat allergic conditions such as hay fever or rashes (like nettle rash or hives) • To treat or stop you feeling sick (nausea) or being sick (vomiting) such as travel sickness • For short term use: as a sedative for children aged 5 years and above Phenergan 25 mg Tablets promethazine hydrochloride Is this leaflet hard to see or read? What you need to know before you take Phenergan Tablets Phone 08 for help Read all of this leaflet carefully before you start taking this medicine because it contains important information for you. • Always take this medicine exactly as described in this leaflet or as your doctor or pharmacist has told you. You may need to read it again • Ask your pharmacist if you need more information or advice • If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. • You must talk to a doctor if you do not feel better or if you feel worse after 7 days. Do not take this medicine if:  The person taking the medicine is under 5 years of age  You are allergic (hypersensitive) to promethazine hydrochloride or any of the other ingredients of Phenergan Tablets (listed in Section 6 below). The signs of an allergic reaction include: a rash, swallowing or breathing problems, swelling of your lips, face, throat or tongue  You are taking a medicine for depression called a monoamine oxidase inhibitor (MAOI). Also do not take Phenergan Tablets if you have stopped taking one of these MAOI medicines within the last 14 days. If you are not sure ask your doctor or pharmacist (see “Taking other medicines” section below)  The person is unconscious (in a coma) or suffers from severe dizziness, drowsiness or headache Do not take this medicine if any of the above applies to you. Contents of the pack and other Information Warnings and precautions Check with your doctor or pharmacist before taking your medicine if  You have difficulty breathing, wheezing, tightness in the chest (asthma) or an infection in your lungs (bronchitis)  You have epilepsy  You have any serious heart problems  You have liver or kidney problems  You have a stomach blockage or difficulty passing water 1.

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    PACKAGE LEAFLET: INFORMATION FOR THE USER PHENERGAN® 25mg TABLETS / PROMETHAZINE HYDROCHLORIDE 25mg TABLETS (promethazine hydrochloride) This medicine is available as any of the above names but will be referred to as Phenergan Tablets throughout the following leaflet. Read all of this leaflet carefully before you start taking this medicine because it contains important information for you. • Ask your pharmacist if you need more information or advice. WHAT PHENERGAN TABLETS ARE AND WHAT THEY ARE USED FOR Phenergan Tablets contain a medicine called promethazine hydrochloride. • Always take this medicine exactly as described in this leaflet or as your doctor or pharmacist has told you. • If you get any side effects, talk to your doctor or pharmacist. This belongs to a group of medicines called phenothiazines. This includes any possible side effects not listed in this leaflet. • You must talk to a doctor if you do not feel better or if you feel worse after 7 days. What Phenergan Tablets are and what they are used for 2. It works by blocking a natural substance (histamine) that your body makes during an allergic reaction. What you need to know before you take Phenergan Tablets 3. It also works directly on the brain to help you feel more relaxed. What Phenergan Tablets are used for Phenergan Tablets are used to treat the following conditions: • For short term use: to treat adults with difficulty sleeping (insomnia) • To treat allergic conditions such as hay fever or rashes (like nettle rash or hives) • To treat or stop you feeling sick (nausea) or being sick (vomiting) such as travel sickness • For short term use: as a sedative for children aged 5 years and above 2. WHAT YOU NEED TO KNOW BEFORE YOU TAKE PHENERGAN TABLETS Do not take this medicine if: • The person taking the medicine is under 5 years of age • You are allergic (hypersensitive) to promethazine hydrochloride or any of the other ingredients of Phenergan Tablets (listed in Section 6 below). The Patient Information Leaflet (PIL) is the leaflet included in the pack with a medicine. It is written for patients and gives information about taking or using a medicine. It is possible that the leaflet in your medicine pack may differ from this version because it may have been updated since your medicine was packaged. Below is a text only representation of the Patient Information Leaflet. The original can be viewed in PDF format using the link above. The text only version may be available from RNIB in large print, Braille or audio CD. What Phenergan Tablets are and what they are used for Phenergan Tablets contain a medicine called promethazine hydrochloride. For further information call RNIB Medicine Leaflet Line on 08. This belongs to a group of medicines called phenothiazines.

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    Mild/moderate: 500 mg PO q12hr or 400 mg IV q12hr for 7-14 days Severe/complicated: 750 mg PO q12hr or 400 mg IV q8hr for 7-14 days Limitations-of-use: Reserve fluoroquinolones for patients who do not have other available treatment options for acute bacterial exacerbation of chronic bronchitis Acute uncomplicated: Immediate-release, 250 mg PO q12hr for 3 days; extended-release, 500 mg PO q24hr for 3 days Mild/moderate: 250 mg PO q12hr or 200 mg IV q12hr for 7-14 days Severe/complicated: 500 mg PO q12hr or 400 mg IV q12hr for 7-14 days Limitations-of-use: Reserve fluoroquinolones for patients who do not have other available treatment options for uncomplicated urinary tract infections Dry powder for inhalation: Orphan designation for patients with NCFB who suffer from frequent severe acute pulmonary bacterial exacerbations which lead to further inflammation, airway, and lung parenchyma damage Indication for treatment and prophylaxis of plague due to Yersinia pestis in pediatric patients from birth to 17 years of age 15 mg/kg PO q8-12hr x10-21 days; not to exceed 500 mg/dose, OR 10 mg/kg IV q8-12hr x 10-21 days; not to exceed 400 mg/dose Postexposure therapy IV: 10 mg/kg q12hr for 60 days; individual dose not to exceed 400 mg PO: 15 mg/kg q12hr for 60 days; individual dose not to exceed 500 mg Change antibiotic to amoxicillin as soon as penicillin susceptibility confirmed Nausea (3%) Abdominal pain (2%) Diarrhea (2% adults; 5% children) Increased aminotransferase levels (2%) Vomiting (1% adults; 5% children) Headache (1%) Increased serum creatinine (1%) Rash (2%) Restlessness (1%) Acidosis Allergic reaction Angina pectoris Anorexia Arthralgia Ataxia Back pain Bad taste Blurred vision Breast pain Bronchospasm Diplopia Dizziness Drowsiness Dysphagia Dyspnea Flushing Foot pain Hallucinations Hiccups Hypertension Hypotension Insomnia Irritability Joint stiffness Lethargy Migraine Nephritis Nightmares Oral candidiasis Palpitation Photosensitivity Polyuria Syncope Tachycardia Tinnitus Tremor Urinary retention Vaginitis Acute generalized exanthematous pustulosis (AGEP), erythema multiforme, exfoliative dermatitis, fixed eruption, photosensitivity/phototoxicity reaction Agitation, confusion, delirium Agranulocytosis, albuminuria, serum cholesterol and TG elevations, blood glucose disturbances, hemolytic anemia, marrow depression (life threatening), pancytopenia (life threatening or fatal outcome), potassium elevation (serum) Anaphylactic reactions (including life-threatening anaphylactic shock), serum sickness like reaction, Stevens-Johnson syndrome Anosmia, hypesthesia Constipation, dyspepsia, dysphagia, flatulence, hepatic failure (including fatal cases), hepatic necrosis, jaundice, pancreatitis Hypertonia, hypotension (postural), increased INR (in patients treated with Vitamin K antagonists), QT prolongation, torsade de pointes, ventricular arrhythmia Methemoglobinemia Myasthenia, exacerbation of myasthenia gravis, myoclonus, nystagmus, peripheral neuropathy that may be irreversible, phenytoin alteration (serum), polyneuropathy, psychosis Myalgia, tendinitis, tendon rupture, toxic epidermal necrolysis (Lyell’s Syndrome), twitching Infections: Candiduria, vaginal candidiasis, moniliasis (oral, gastrointestinal, vaginal), pseudomembranous colitis Renal calculi Vasculitis Because the risk of these serious side effects generally outweighs the benefits for patients with acute bacterial sinusitis, acute exacerbation of chronic bronchitis, and uncomplicated UTIs, that fluoroquinolones should be reserved for use in patients with these conditions who have no alternative treatment options Use in pregnancy, though generally contraindicated for all quinolones, is allowed for life-threatening situations; 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peripheral neuropathy may occur rapidly after initiating and may potentially become permanent In prolonged therapy, perform periodic evaluations of organ system functions (eg, renal, hepatic, hematopoietic); adjust dose in renal impairment; superinfections may occur with prolonged or repeated antibiotic therapy; discontinue use immediately if signs and symptoms of hepatitis occur Not first drug of choice in pediatrics (except in anthrax), because of increased incidence of adverse events in comparison with control subjects, including arthropathy; no data exist on dosing for pediatric patients with renal impairment (ie, Cr Cl Distributed widely throughout body; tissue concentrations often exceed serum concentrations, especially in kidneys, gallbladder, liver, lungs, gynecologic tissue, and prostatic tissue; cerebrospinal fluid (CSF) concentration is 10% in noninflamed meninges and 14-37% in inflamed meninges; crosses placenta; enters breast milk Protein bound: 20-40% Vd: 2.1-2.7 L/kg Additive: Aminophylline, amoxicillin, amoxicillin-clavulanate, amphotericin, ampicillin-sulbactam, ceftazidime, cefuroxime, clindamycin, floxacillin, heparin, piperacillin, sodium bicarbonate, ticarcillin Y-site: Aminophylline, ampicillin-sulbactam, azithromycin, cefepime, dexamethasone sodium phosphate, furosemide, heparin, hydrocortisone sodium succinate, magnesium sulfate(? ), methylprednisolone sodium succinate, phenytoin, potassium phosphates, propofol, sodium bicarbonate(? ), sodium phosphates, total parenteral nutrition formulations, warfarin Solution: Compatible with most IV fluids Additive: Amikacin, aztreonam, dobutamine, dopamine, fluconazole, gentamicin, lidocaine, linezolid, metronidazole (ready-to-use form is compatible; 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