side effect of tamoxifen is blood clots, including deep vein thrombosis (DVT) and pulmonary embolus. In some cases, health care professionals may use the trade name Nolvadex when referring to the generic drug name tamoxifen. This medication is classified as an "anti-estrogen." (For more detail, see "How this drug works" section below). You should seek emergency help and notify your health care provider immediately if you develop sudden chest pain and shortness of breath. Notify your health care provider within 24 hours if you notice that one leg is swollen, red, painful and/or warm to touch and the other is not. A side effect of tamoxifen can be the development of uterine cancer. Women who have not had a hysterectomy should have regular pap smears and gyn examinations. Abnormal vaginal bleeding should be reported to your health care provider. Tamoxifen (Nolvadex) has been used for over 40 years to treat hormone-receptor positive early, locally advanced and metastatic breast cancers. Learn about tamoxifen and other hormone therapies for metastatic breast cancer. Hormone receptor-positive breast cancers need estrogen and/or progesterone (female hormones produced in the body) to grow. Tamoxifen attaches to the hormone receptor in the cancer cell, blocking estrogen from attaching to the receptor. This slows or stops the growth of the tumor by preventing the cancer cells from getting the hormones they need to grow. Tamoxifen is a pill taken every day for 5-10 years. For premenopausal women, tamoxifen may be combined with ovarian suppression. The benefits from tamoxifen last long after you stop taking it. Metformin and cancer Where to order lasix Where can i buy viagra in the uk Tamoxifen has a wide range of systemic effects, possibly acting on every estrogen. 2 to 4 times higher than for postmenopausal women not taking tamoxifen. And there are a few serious possible side effects to tamoxifen that other endocrine therapies, such as aromatase inhibitors like anastrozole Arimidex, do not share. Side effects include increased risk of blood clots in the lungs and legs, stroke, and endometrial and uterine cancers. The benefits and harms of taking hormone therapy should be carefully weighed for each woman. A common switching strategy used for adjuvant therapy, in which patients take tamoxifen for 2 or 3 years, followed by an aromatase inhibitor for 2 or 3 years, may yield the best balance of benefits and harms of these two types of hormone therapy. Tamoxifen is a hormone therapy drug taken by many premenopausal women after completing their initial treatments for estrogen receptor positive breast cancer. To treat the side effects of tamoxifen (such as hot flashes) and to help with depression, doctors often prescribe antidepressants. Yet many antidepressants can interfere, or completely cancel out, the benefits of tamoxifen. Once a woman is finished with the primary treatment of breast cancer, with therapies such as surgery, chemotherapy, and radiation therapy, she may need to take tamoxifen. For women who have estrogen receptor positive tumors, hormone therapy can reduce the risk of the cancer coming back (recurrence) by around 50 percent. The choice of medication depends on menopausal status. If a woman is premenopausal, tamoxifen is usually the drug of choice. (For those who are postmenopausal, or who are premenopausal but have received ovarian suppression therapy, an aromatase inhibitor is usually used instead). Tamoxifen (Nolvadex®) is a medication in pill form that has been used for more than 25 years to treat breast cancer in women and men. Tamoxifen is one of the most common endocrine therapy drugs. It has been shown to decrease the chance of recurrence in some early-stage breast cancers and to prevent the development of cancer in the opposite breast. Tamoxifen can also slow or stop the growth of cancer cells present in the body. There are an estimated 29 million women at increased risk for breast cancer in this country, and tamoxifen may offer another alternative to watchful waiting or prophylactic (preventative) mastectomy. Tamoxifen is classified as a selective estrogen receptor modulator (SERM) and works as an anti-estrogen: While the hormone estrogen promotes the growth of breast cancer cells, tamoxifen works by blocking estrogen from attaching to estrogen receptors on these cells. By blocking the estrogen receptors, it is believed that the growth of the breast cancer cells will be halted. Why not to take tamoxifen Antidepressants That Interact With Tamoxifen - Verywell Health, Do I Have To Take Tamoxifen – Women’s Health Network Xanax before surgery I elected not to take tamoxifen. I already have too many lingering side effects from the chemo drugs and at 50/50 odds I'll take my chances. In 1996, the State of California added tamoxifen to its list--Proposition 65--of known cancer causing chemicals. Take Tamoxifen or Not? I am Torn! Please help Cancer.. Hormone Therapy for Breast Cancer Fact Sheet - National.. To Tamoxifen or not? - Breast Cancer Network Australia. I think the worst thing that could happen, on a public health basis, with this paper is for patients and their doctors to look at this and say, 'Oh, this is a reason not to take tamoxifen.' Before taking this medicine. You should not use tamoxifen if you are allergic to it. You should not use tamoxifen to reduce your risk of breast cancer if you are also taking a blood thinner such as warfarin Coumadin, Jantoven. Do not take tamoxifen if you are pregnant. It could harm the unborn baby. Mrs. TR is not alone. Support for tamoxifen in breast cancer prevention is bafflingly low amongst both doctors and patients, though it is routinely used for treatment. There is a pill out there to prevent breast cancer — it’s just that most women are finding it hard to swallow.